Clopidogrel, a Platelet P2Y12 Receptor Inhibitor, Reduces Vascular Inflammation and Angiotensin II Induced-Abdominal Aortic Aneurysm ProgressionReport as inadecuate




Clopidogrel, a Platelet P2Y12 Receptor Inhibitor, Reduces Vascular Inflammation and Angiotensin II Induced-Abdominal Aortic Aneurysm Progression - Download this document for free, or read online. Document in PDF available to download.

Medial degeneration and inflammation are features of abdominal aortic aneurysms AAAs. However, the early inflammatory event initiating aneurysm formation remains to be identified. Activated platelets release abundant proinflammatory cytokines and are involved in initial inflammation in various vascular diseases. We investigated the role of platelets in progression of AAA in vivo and in vitro. Histological studies of tissues of patients with AAA revealed that the number of platelets was increased in aneurysm sites along with the increased infiltration of T lymphocytes and augmented angiogenesis. In a murine model of AAA, apolipoprotein E-knockout mice infused with 1,000 ng-kg-min angiotensin II, treatment with clopidogrel, an inhibitor of platelets, significantly suppressed aneurysm formation 47% decrease, P<0.05. The clopidogrel also suppressed changes in aortic expansion, elastic lamina degradation and inflammatory cytokine expression. Moreover, the infiltration of macrophages and production of matrix metalloproteinases MMPs were also significantly reduced by clopidogrel treatment. In vitro incubation of macrophages with isolated platelets stimulated MMP activity by 45%. These results demonstrate a critical role for platelets in vascular inflammation and AAA progression.



Author: Ou Liu, Lixin Jia, Xiaoxi Liu, Yueli Wang, Xiaolong Wang, Yanwen Qin, Jie Du , Hongjia Zhang

Source: http://plos.srce.hr/



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