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Since Autism Spectrum Disorder ASD is stronglyassociated with chromosomal abnormalities of 16p11.2, and Autism has beenlinked to neuronal polarity defect, our study aimed to explore the role of 16p11.2genes in regulating neuronal polarity. We performed a neuronal polarity assayin a high throughput manner for candidate genes at 16p11.2. Our mostinteresting finding was that three 16p11.2 candidate genes, DOC2a, Tbx-6 and KIF 22, affected neuronal polarity.Our research, for the first time, indicates a novel association between 16p11.2and neuronal polarity. Our results support the hypothesis that 16p11.2 isrequired for neuronal polarity. Our research provides new important insightsinto molecular mechanisms underlying the tight association between 16p11.2 andseveral neural developmental disorders, including autism, epilepsy, mentalretardation and schizophrenia.

KEYWORDS

Neuronal Polarity; 16p11.2; Autism; Epilepsy; Neuronal Development

Cite this paper

Li, Z. , He, X. and Feng, J. 2013 16p11.2 is required for neuronal polarity. World Journal of Neuroscience, 3, 221-227. doi: 10.4236-wjns.2013.34029.





Author: Zhi Li, Xi He, Jiexiong Feng

Source: http://www.scirp.org/



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