Low SIRT3 Expression Correlates with Poor Differentiation and Unfavorable Prognosis in Primary Hepatocellular CarcinomaReport as inadecuate




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SIRT3, a mitochondrial sirtuin belonging to nicotinamide adenine nucleotide NAD dependent deacetylases, is implicated in metabolism, longevity and carcinogenesis. SIRT3 expression and its significance in hepatocellular carcinoma HCC remain largely unclear. In this study, we demonstrated that SIRT3 expression in HCC tissue was much lower than that in paracarcinoma tissue, at both mRNA and protein levels. The cutoff value for low SIRT3 expression in HCC was defined according to receiver operating characteristic curve ROC analysis. As disclosed by immunohistochemistry IHC results, low SIRT3 expression was present in 67.3% 167-248 of HCC cases. Furthermore, low expression of SIRT3 was significantly correlated to differentiation P = 0.013, clinical stage P = 0.005, serum AFP level P<0.01, tumor multiplicity P = 0.026 and relapse P = 0.028. Moreover, Kaplan-Meier analysis indicated that low SIRT3 expression associated with unfavorable overall survival P<0.01 and recurrence-free survival P = 0.004. The prognostic impact of SIRT3 was further confirmed by stratified survival analysis. Importantly, multivariate analysis revealed that low SIRT3 expression was an independent poor prognostic marker for overall survival Hazard Ratio HR 0.555, 95% confidence interval 95% CI 0.344–0.897, P = 0.016. Collectively, we conclude that SIRT3 is decreased in HCC and is a novel unfavorable marker for prognosis of patients with this fatal disease.



Author: Chris Zhiyi Zhang, Lili Liu, Muyan Cai, Yinghua Pan, Jia Fu, Yun Cao, Jingping Yun

Source: http://plos.srce.hr/



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