MiR-27 as a Prognostic Marker for Breast Cancer Progression and Patient SurvivalReport as inadecuate




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Background

MicroRNA-27a miR-27a is thought to be an onco-microRNA that promotes tumor growth and metastasis by downregulating ZBTB10. The potential predictive value of miR-27a was studied in breast cancer patients.

Methods

The expression of miR-27a and ZBTB10 was examined in 102 breast cancer cases using in situ hybridization ISH and immunohistochemistry techniques and were evaluated semi-quantitatively by examining the staining index. The Correlation of miR-27a and ZBTB10 expression was analyed by Spearman Rank Correlation. The association of miR-27a and ZBTB10 expression with clinicopathological characteristics was analyzed using the χ2 test, and their effects on patient survival were analyzed by a log-rank test and the Kaplan-Meier method. Univariate and multivariate Cox regression analyses were used to evaluate the prognostic values of miR-27a and ZBTB10.

Results

miR-27a was markedly up-regulated in invasive breast cancers that expressed low levels of ZBTB10 P<0.001. A reverse correlation between miR-27a and ZBTB10 was also observed in breast cancer tissue samples rs = −0.478, P<0.001. Furthermore, the expression of miR-27a and ZBTB10 was significantly correlated with clinicopathological parameters, including tumor size, lymph node metastasis and distant metastasis P<0.05, but not with receptor status. Patients with high miR-27a or low ZBTB10 expression tended to have significantly shorter disease-free survival times 57 months and 53 months, respectively, P <0.001 and overall survival times 58 months and 55 months, respectively, P <0.001. Univariate and multivariate analysis showed that both miR-27a and ZBTB10 were independent prognostic factors of disease-free survival in breast cancer patients P <0.001, while only miR-27a was an independent predictor of overall survival P <0.001.

Conclusions

High miR-27a expression is associated with poor overall survival in patients with breast cancer, which suggests that miR-27a could be a valuable marker of breast cancer progression.



Author: Wei Tang , Jiujun Zhu , Shicheng Su, Wei Wu, Qiang Liu, Fengxi Su , Fengyan Yu

Source: http://plos.srce.hr/



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