Serum Glycated Albumin Is Inversely Influenced by Fat Mass and Visceral Adipose Tissue in Chinese with Normal Glucose ToleranceReport as inadecuate




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Background

Recent studies have revealed that body mass index BMI inversely influenced serum glycated albumin GA, which may cause an underestimation of GA-monitored short-term hyperglycemic control.

Objective

This study was to investigate the association between anthropometric variables BMI and waist circumference W and accurate adiposity variables percentage of body fat %fat, fat mass, free fat mass FFM, subcutaneous fat area SFA, and visceral fat area VFA with serum GA.

Design

A total of 2563 subjects 1037 men, 593 premenopausal women, and 933 postmenopausal women with normal glucose tolerance underwent bioelectrical impedance body fat content measurement and magnetic resonance imaging. Serum GA and absolute value of GA aGA were measured by enzymatic assay.

Results

Compared to the BMI <25.0 kg-m2 group, the BMI ≥25.0 kg-m2 group had significantly higher fasting plasma glucose, glycated hemoglobin A1c, and body fat parameters including W, %fat, fat mass, FFM, SFA, and VFA, but significantly lower aGA, and GA in all the three sex- and menopause-stratified groups all P<0.05. GA decreased with the increment of fat mass for all three groups all P for trend <0.001. In the same BMI category, men and postmenopausal women with elevated %fat men, ≥25%; women, ≥35% still had significantly lower GA than those with normal %fat men, <25%; women, <35% all P<0.05. Multiple stepwise regression showed that %fat, fat mass, and VFA were independently associated with GA.

Conclusions

Serum GA was inversely influenced by fat mass and visceral adipose tissue in Chinese with normal glucose tolerance.



Author: Feifei Wang , Xiaojing Ma , Yaping Hao, Rong Yang, Jie Ni, Yunfeng Xiao, Junling Tang, Yuqian Bao , Weiping Jia

Source: http://plos.srce.hr/



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