Vitamin B-12 Status during Pregnancy and Child’s IQ at Age 8: A Mendelian Randomization Study in the Avon Longitudinal Study of Parents and ChildrenReport as inadecuate




Vitamin B-12 Status during Pregnancy and Child’s IQ at Age 8: A Mendelian Randomization Study in the Avon Longitudinal Study of Parents and Children - Download this document for free, or read online. Document in PDF available to download.

Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort ALSPAC. We then examined the association of SNPs in maternal genes FUT2 rs492602 and TCN2 rs1801198, rs9606756 that are related to plasma vitamin B-12, with offspring IQ. Observationally, there was a positive association between maternal vitamin B-12 intake and child’s IQ that was markedly attenuated after adjustment for potential confounders mean difference in offspring IQ score per doubling of maternal B-12 intake, before adjustment: 2.0 95% CI 1.3, 2.8; after adjustment: 0.7 95% CI −0.04, 1.4. Maternal FUT2 was weakly associated with offspring IQ: mean difference in IQ per allele was 0.9 95% CI 0.1, 1.6. The expected effect of maternal vitamin B-12 on offspring IQ, given the relationships between SNPs and vitamin B-12, and SNPs and IQ was consistent with the observational result. Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted.



Author: Carolina Bonilla , Debbie A. Lawlor, Amy E. Taylor, David J. Gunnell, Yoav Ben–Shlomo, Andrew R. Ness, Nicholas J. Timpson, Bea

Source: http://plos.srce.hr/



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