Sialochemistry in Patients with Oral Lichen PlanusReport as inadecuate

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Acta stomatologica Croatica, Vol.45 No.3 September 2011. -

Objective: It is well known that certain salivary constituents might be disturbed in patients suffering from oral lichen planus OLP, however, the results of the published studies are inconsistent. The aim of this study was to assess the concentrations of salivary analytes because most of them are part of salivary enzymes which maintain integrity of the oral mucosa which is compromised in OLP patients. Materials and Methods: In 25 patients with OLP 73±1.4 yrs and in the 24 controls 24±3.7yrs levels of total proteins, amylase, salivary magnesium, calcium, copper, chloride, phosphate, potassium and sodium were determined. Total proteins were determined by pyrogalol colorimetric method. Amylase levels were determined by continued colorimetric method. Salivary sodium, potassium and chloride were determined by indirect potentiometry whereas salivary

copper and magnesium were determined by atomic absorption spectrophotometry whereas phosphates were determined by colorimetric method with use of molybdate. Statistical analysis was performed by use of χ2 test, Mann Whitney U test analysis of covariance and Spearmans correlation. Results: Significantly higher concentration of salivary chloride was detected in OLP patients in comparison to the controls p=0.025. Furthermore, when the obtained results for salivary analytes were adjusted with respect to the salivary flow rate, increased levels of salivary potassium, sodium, chloride and total proteins were found in patients with OLP when compared to the controls p=0.622; p=0.504; p=0.600; p=0.586. Concentrations of salivary analytes were not affected by smoking habit. Conclusions: Increased levels of salivary sodium, potassium and chloride are probably a result of significant differences in salivary flow rate between patients with OLP and controls and do not indicate increased salivary antimicrobial activity.

Saliva; Lichen Planus, Oral; Salivary Proteins and Peptides

Author: Vanja VUČIĆEVIĆ BORAS - ; Department of Oral Medicine, School of Dentistry, Gundulićeva 5, Zagreb, Croatia Dunja Rogić - ; L



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