Protective Effects of Many Citrus Flavonoids on Cartilage Degradation ProcessReport as inadecuate




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The objective of this study was to investigate the effects of many citrus flavanones, such as neoeriocitrin, naringin and neohesperidin, in cartilage degradation. Degenerative joint disease involved degradation of joints, including articular cartilage and subchondral bone. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. The degradation cartilage is mediated by alteration of the balance between anabolic and catabolic processes, changes in proteolytic enzyme activity, mechanical disruption of the cartilage extracellular matrix ECM, or a combination of these processes. We examine the capability of neoeriocitrin, naringin and neohesperidin, to inhibit metalloproteinase MMP-13, collagenase involved in degradation of cartilage matrix components. Also, we assay the flavonoids effect on reducing of Glycosaminoglycans GAGs release, and restore Nitric oxide NO levels in explant of human articular cartilage. Our results suggest that neoeriocitrin, naringin and neohesperidin are a potential therapeutic agent to protect cartilage tissue.

KEYWORDS

Neoeriocitrin; Naringin; Neohesperidin; Metalloproteinases-13; Cartilage Degradation

Cite this paper

L. Crascì and A. Panico -Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process,- Journal of Biomaterials and Nanobiotechnology, Vol. 4 No. 3, 2013, pp. 279-283. doi: 10.4236-jbnb.2013.43035.





Author: Lucia Crascì, Annamaria Panico

Source: http://www.scirp.org/



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