The Research of Nanocrystallized Realgar for the Treatment of Skin CancerReport as inadecuate




The Research of Nanocrystallized Realgar for the Treatment of Skin Cancer - Download this document for free, or read online. Document in PDF available to download.

Objective: To observe the effects and mechanisms of nanocrystallized realgar for the treatment of skin cancer. Methods: The clinical part was observing the therapeutic effect for the skin ulceration by externally using the nanocrystallized realgar. The experimental part was culturing the human squamous cell carcinoma A431 cells A431 in vitro environment, estimating the effects of proliferation and apoptosis of A431 by MTT method and flow cytometry, and observing the effects on the expression of Survivin, Caspase-3 by RT-PCR method. Results: External treatment with nanocrystallized realgar had a therapeutic effect for the skin ulceration; it can promote the ulcers of skin cancer and skin metastasis healing. The experiments confirmed that nanocrystallized realgar can inhibit the A431 proliferation, induce the cells apoptosis, promote the expression of Caspase-3 and reduce the expression of Survivin. And the experiments also found that the effects were in a concentration-dependent manner, and they have a synergistic effect with cis-Dichlorodiamineplatinum DDP. Conclusions: External treatment with nanocrystallized realgar for the patients of skin cancer or skin metastasis achieved satisfactory therapeutic effects by inhibiting A431 proliferation and inducing these cells apoptosis. The mechanism might be associated with promoting the expression of Caspase-3 and reducing the expression of Survivin.

KEYWORDS

Skin Cancer; Nanocrystallized Realgar; Ulceration; Inhibition of Proliferation; Induction of Apoptosis

Cite this paper

Y. Qi, X. Li, H. Li and Y. Zheng -The Research of Nanocrystallized Realgar for the Treatment of Skin Cancer,- Journal of Cancer Therapy, Vol. 4 No. 6A, 2013, pp. 43-47. doi: 10.4236-jct.2013.46A1007.





Author: Yuanfu Qi, Xiurong Li, Huijie Li, Yi Zheng

Source: http://www.scirp.org/



DOWNLOAD PDF




Related documents