The CREB-miR-9 Negative Feedback Minicircuitry Coordinates the Migration and Proliferation of Glioma CellsReport as inadecuate




The CREB-miR-9 Negative Feedback Minicircuitry Coordinates the Migration and Proliferation of Glioma Cells - Download this document for free, or read online. Document in PDF available to download.

Migration-proliferation dichotomy is a common mechanism in gliomagenesis; however, an understanding of the exact molecular mechanism of this -go or grow- phenomenon remains largely incomplete. In the present study, we first found that microRNA-9 miR-9 is highly expressed in glioma cells. MiR-9 inhibited the proliferation and promoted the migration of glioma cells by directly targeting cyclic AMP response element-binding protein CREB and neurofibromin 1 NF1, respectively. Our data also suggested a migration-inhibitory role for CREB through directly regulating the transcription of NF1. Furthermore, we found that the transcription of miR-9-1 is under CREB-s control, forming a negative feedback minicircuitry. Taken together, miR-9 inhibits proliferation but promotes migration, whereas CREB plays a pro-proliferative and anti-migratory role, suggesting that the CREB-miR-9 negative feedback minicircuitry plays a critical role in the determination of -go or grow- in glioma cells.



Author: Xiaochao Tan, Shan Wang, Bin Yang, Liyuan Zhu, Bin Yin, Tengfei Chao, Jizong Zhao, Jiangang Yuan, Boqin Qiang , Xiaozhong Peng

Source: http://plos.srce.hr/



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