Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV-HCV Genotype 3 PatientsReport as inadecuate




Differences in HCV Viral Decline between Low and Standard-Dose Pegylated-Interferon-Alpha-2a with Ribavirin in HIV-HCV Genotype 3 Patients - Download this document for free, or read online. Document in PDF available to download.

Background

The aim of the study was to analyze the different impact of standard and low-dose Peg-IFN-α2a-RBV therapies on HCV viral decline in HIV-HCV genotype 3 co-infected patients during the first weeks of treatment.

Methods

Plasma HCV viral decline was analyzed between baseline and weeks 1, 2 and 4 in two groups of treatment-naïve HCV genotype 3 patients with HIV co-infection. The Standard Dose Group SDG included patients who received Peg-IFN at 180 µg-per week with a weight-adjusted dose of ribavirin; Low-Dose Group LDG patients received Peg-IFN at 135 µg-per week with 800 mg-day ribavirin. The effect of IL28B genotype on HCV viral decline was evaluated in both groups. HCV viral decline was analyzed using a multivariate linear regression model.

Results

One hundred and six patients were included: 48 patients in the SDG and 58 in the LDG. HCV viral decline for patients in the LDG was less than for those in the SDG week 1∶1.72±0.74 log10 IU-mL versus 1.78±0.67 log10 IU-mL, p = 0.827; week 2∶2.3±0.89 log10 IU-mL versus 3.01±1.02 log10 IU-mL, p = 0.013; week 4∶3.52±1.2 log10 IU-mL versus 4.09±1.1 log10 IU-mL, p = 0.005. The linear regression model identified the Peg-IFN-RBV dose as an independent factor for HCV viral decline at week 4.

Conclusions

Our results showed that HCV viral decline was less for patients in the low-dose group compared to those receiving the standard dose. Until a randomized clinical trial is conducted, clinicians should be cautious about using lower doses of Peg-IFN-RBV in HIV-HCV genotype 3 co-infected patients.



Author: Antonio Rivero-Juárez, Luis F. Lopez-Cortes, Angela Camacho, Almudena Torres-Cornejo, Juan A. Pineda, Manuel Marquez-Solero, Ant

Source: http://plos.srce.hr/



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