Hippocampal High-Frequency Stimulation Inhibites the Progression of Rapid Kindling-Induced Seizure in RatsReport as inadecuate




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Epilepsy is one of themost common serious neurological disorders. Pharmacoresistant epilepsy patientsare poorly controlled or their seizures are refractory to drug treatment.Resective surgery is frequently a promising therapy in this population,however, not all the patients meet the eligibility criteria for the surgicaltreatment. Deep brain stimulation hasbeen investigated in clinical studies and animal studies as an alternativetreatment, but the optimal stimulation parameters remain an issue. The present study was designed to investigate the effect of unilateral high-frequency stimulation HFS ofhippocampus on seizure development by using the hippocampal rapid kindlingmethod hRK in rats, and compared the results with those of low-frequency stimulation previously published byour group. We used male Wistar rats implanted with electrodes in the ventralhippocampus. All rats underwent hRK biphasic square wave pulses, 20 Hz for 10seconds during three consecutive days twelve stimulations per day. Thecontrol group hRK; n = 7 received only RK stimulus, whilethe treated group HFS-hRK; n = 9 received alsoHFS biphasic square wave pulses, 130 Hz for 30 seconds immediately before theRK stimulus, during three consecutive days. At the end of behavioral testing78% p



Author: Belen Gori, Magdalena Pereyra, Lucas Toibaro, Carola Brescacin, Gerardo Battaglia, Julieta Pastorino, Ariela Smigliani, Milagros

Source: http://www.scirp.org/



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