Analysis of the Interferon Gamma rs2430561, 874T-A Functional Gene Variant in Relation to the Presence of Cardiovascular Events in Rheumatoid ArthritisReport as inadecuate




Analysis of the Interferon Gamma rs2430561, 874T-A Functional Gene Variant in Relation to the Presence of Cardiovascular Events in Rheumatoid Arthritis - Download this document for free, or read online. Document in PDF available to download.

Objective

Rheumatoid arthritis RA is a chronic inflammatory disease associated with increased cardiovascular CV morbidity and mortality. Since interferon-gamma IFN-γ has a direct effect on inflammation, in this study we assessed the potential association of the IFNG functional gene variant rs2430561 with CV disease in patients with RA.

Methods

One thousand six hundred and thirty-five patients fulfilling the 1987 American College of Rheumatology classification criteria for RA were genotyped for the IFNG rs2430561, +874T-A gene polymorphism using TaqMan genotyping assay. Patients were stratified according to the presence of CV events or not. Logistic regression models to explain the presence of CV disease according to the IFNG rs2430561 allele distribution were performed. The potential influence of this variant in the development of subclinical atherosclerosis was also analyzed in a subgroup of patients with no history of CV events to determine carotid artery intima-media thickness IMT n = 286 and presence of carotid plaques. Levels of the cytokine were determined in a subgroup of patients by ELISA.

Results

Adjusted logistic regression model disclosed that presence of the minor allele A was not associated with increased risk of suffering CV events in RA patients. Besides, differences did not achieve statistical significance regarding carotid IMT and presence of carotid plaques in RA patients carrying IFNG rs2430561 variant allele. Levels of IFN-γ were higher in patients who had suffered CV events compared to patients who did not.

Conclusion

Our results do not support a role of IFNG rs2430561 +874T-A functional gene variant in the development of CV disease in RA patients.



Author: Mercedes García-Bermúdez , Raquel López-Mejías , Carlos González-Juanatey, Alfonso Corrales, Gema Robledo, Santos Castañeda

Source: http://plos.srce.hr/



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