Perioperative Clinical Interventions That Modify the Immune Response in Cancer PatientsReport as inadecuate




Perioperative Clinical Interventions That Modify the Immune Response in Cancer Patients - Download this document for free, or read online. Document in PDF available to download.

The immune system plays a pivotal roleagainst cancer. The development of a successful immune response involves thebalance between the Th1 antitumor and Th2 protumor responses. Once thisbalance is lost, diseases such as cancer may become apparent. Surgical stress,volatile anaesthetics, opioids and blood transfusions are known to favour a Th2response that manifests as immune suppression. During surgery the load of circulating malignantcancer cells is increasedby tumour manipulation. These cancer cells can migrate and seed in distanttissues and form metastasis. Also, some cancer patients may present withmicrometastasis that may become invasive if left untreated. Therefore, the perioperative period is a moment ofimmunological vulnerability in cancer patients. A better understanding of thefactors that affect the Th1-Th2 balance may allow anaesthesiologists toidentify patients at high risk for cancer recurrence. This review describes theperioperative interventions that can alter the Th1-Th2 balance, during theperioperative period of oncological surgery.

KEYWORDS

Neoplasm; Surgery; Anaesthesia; Cytokines; Neoplasm Recurrence; Immune Response; Opioids; Volatile Anaesthetics

Cite this paper

M. Ramírez, J. Huitink and J. Cata -Perioperative Clinical Interventions That Modify the Immune Response in Cancer Patients,- Open Journal of Anesthesiology, Vol. 3 No. 3, 2013, pp. 133-139. doi: 10.4236-ojanes.2013.33031.





Author: María F. Ramírez, Johannes M. Huitink, Juan P. Cata

Source: http://www.scirp.org/



DOWNLOAD PDF




Related documents