BioFET-SIM Web Interface: Implementation and Two ApplicationsReport as inadecuate




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We present a web interface which allows us to conveniently set up calculations based on the BioFET-SIM model. With the interface, the signal of a BioFET sensor can be calculated depending on its parameters, as well as the signal dependence on pH. As an illustration, two case studies are presented. In the first case, a generic peptide with opposite charges on both ends is inverted in orientation on a semiconducting nanowire surface leading to a corresponding change in sign of the computed sensitivity of the device. In the second case, the binding of an antibody-antigen complex on the nanowire surface is studied in terms of orientation and analyte-nanowire surface distance. We demonstrate how the BioFET-SIM web interface can aid in the understanding of experimental data and postulate alternative ways of antibody-antigen orientation on the nanowire surface.



Author: Martin R. Hediger , Jan H. Jensen, Luca De Vico

Source: http://plos.srce.hr/



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