Intracellular Transport of HIV-1 Matrix Protein Associated with Viral RNAReport as inadecuate




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HIV-1matrix protein MA is a multifunctional structural protein localized on N terminusof Gag precursor p55. MA participates in HIV-1 assembly as membranotropic part ofGag precursor as well as an individual protein spliced from Gag early in infection.MA is found in the nuclei of infected cells and in plasma membrane, the site ofvirus assembly, in association with viral genome RNA. MA mutated variant M4 whichcontains two changed amino acids in N-terminal regions is also associated with viralRNA, but it is localized in the nuclear and cytoskeleton fractions but not in theplasma membrane suggesting that the mutant is deprived of membranotropic signaland -sticks- in the nuclei an d cytoskeleton, its previous location sites. Thesedata allow suggesting that MA involved into transmission of viral RNA is transportedto plasma membrane by cytoskeleton.

KEYWORDS

HIV-1 Matrix Protein; Gag Precursor P55; Cytoskeleton; Viral RNA; Transport of Viral Complex; Plasma Membranes; Cell Fractionatiomn

Cite this paper

A. Gozhenko, V. Divocha, G. Vorkunova, A. Bukrinskaya and S. Lupandin -Intracellular Transport of HIV-1 Matrix Protein Associated with Viral RNA,- World Journal of AIDS, Vol. 3 No. 1, 2013, pp. 33-35. doi: 10.4236-wja.2013.31005.





Author: Anatoliy I. Gozhenko, Valentina A. Divocha, Galina K. Vorkunova, Alissa G. Bukrinskaya, Sergey I. Lupandin

Source: http://www.scirp.org/



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