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Abstract: Since 1984, electric cell-substrate impedance sensing ECIS has been used tomonitor cell behavior in tissue culture and has proven sensitive to cellmorphological changes and cell motility. We have taken ECIS measurements onseveral cultures of non-cancerous HOSE and cancerous SKOV human ovariansurface epithelial cells. By analyzing the noise in real and imaginaryelectrical impedance, we demonstrate that it is possible to distinguish the twocell types purely from signatures of their electrical noise. Our measuresinclude power-spectral exponents, Hurst and detrended fluctuation analysis, andestimates of correlation time; principal-component analysis combines all themeasures. The noise from both cancerous and non-cancerous cultures showscorrelations on many time scales, but these correlations are stronger for thenon-cancerous cells.



Author: D.C. Lovelady, T.C. Richmond, A.N. Maggi, C.-M. Lo, D.A. Rabson

Source: https://arxiv.org/



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