Successful Use of Recombinant Factor VIIa in Traumatic Liver Injury – A Case ReportReport as inadecuate




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Collegium antropologicum, Vol.35 No.1 March 2011. -

The paper describe the use of rFVIIa in the management of massive bleeding in a patient with polytrauma involving

liver injury. An 18-year-old girl with severe polytrauma sustained during a bus–car collision. She had multiple musculoskeletal

injuries, severe concussion of the liver with amputation of the left liver lobe, disruption of the left hepatic

vein from the inferior vena cava, and impaired hemostasis. Acute bleeding >5 L was not improved by conservative

methods and a single dose of rFVIIa 90 g-kg was administered. Infusion of rFVIIa resulted in an immediate clinical effect

with rapid improvements in blood laboratory measurements and coagulation parameters. rFVIIa should be considered

as an adjunctive treatment for the control of hemorrhage in severely injured patients with uncontrolled bleeding

and impaired hemostasis.

recombinant FVIIa; polytrauma; liver; coagulopathy; hemorrhage; hemostasis



Author: Senka Baranović - Ivan Zvonimir Lubina - Tatjana Nikolić - Branka Maldini -

Source: http://hrcak.srce.hr/



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