Vitamin D, Parathyroid Hormone and Their Associations with Hypertension in a Chinese PopulationReport as inadecuate




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Background

Conflicting reports support or refute an association between vitamin D deficiency with high levels of parathyroid hormone PTH and raised blood pressure or hypertension.

Objective

To explore the associations of serum vitamin D and PTH levels with blood pressure and risk of hypertension in a Chinese population.

Methods

A population-based cross-sectional study was conducted among 1,420 Chinese participants, aged 20–83 years, in 2010. Anthropometric phenotypes and blood pressure were evaluated. Serum lipids, 25-hydroxyvitamin D 25OHD and PTH were measured.

Results

One thousand four hundred and twenty participants, including 566 women 39.9%, were evaluated in 2010. Four hundred and eighty seven were hypertensive 34.3%, of whom 214 43.9% received antihypertensive treatment. The median concentrations of serum 25OHD and PTH were 22.0 ng-ml and 2.83 pmol-l, respectively. Serum 25OHD and natural log of PTH levels were not independently associated with blood pressure in a multivariable adjusted linear regression analysis of 1,206 participants not receiving antihypertensive treatment P>0.05. In logistic regression analyses, serum 25OHD levels were not associated with risk of hypertension in single and multiple regression models. One unit increments of natural log of PTH levels were significantly associated with risk of hypertension in the crude model OR = 1.78, 95% confidence interval 1.38–2.28, P<0.0001 and model adjusted for age and sex OR = 1.41, 95% confidence interval 1.08–1.83, P = 0.01. However, these associations were attenuated and became nonsignificant OR = 1.29, 95% confidence interval 0.98–1.70, P = 0.07 after further adjustment for body mass index, current alcohol intake, current smoking, glomerular filtration rate and family history of hypertension.

Conclusions

Serum vitamin D and PTH levels are not independently associated with blood pressure or risk of hypertension in a Chinese population.



Author: Lihua Li , Xueyan Yin, Chaoyong Yao, Xuechuang Zhu, Xinhua Wu

Source: http://plos.srce.hr/



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