Expression of Matrix Metalloproteinase-1 in Uterosacral Ligaments Tissue of Women with Genital ProlapseReport as inadecuate




Expression of Matrix Metalloproteinase-1 in Uterosacral Ligaments Tissue of Women with Genital Prolapse - Download this document for free, or read online. Document in PDF available to download.

Collegium antropologicum, Vol.34 No.4 December 2010. -

Collagen metabolism is altered in the pelvic organ tissues of women with genital prolapse. The aim of this study was to compare collagen metabolism by measuring matrix metalloproteinase – 1 MMP – 1 expression in uterosacral ligament tissues of postmenopausal women with and without genital prolapse. Uterosacral ligament tissues were obtained at the time of abdominal or vaginal surgery from twenty-four patients with pelvic organ prolapse POP and 21 women who underwent gynecologic surgery for benign indications. The tissue samples were analyzed by immunohistochemistry. There were no differences in age, BMI and parity between two groups. The patients with genital prolapse demonstrated significantly higher occurences of MMP – 1 expression compared to controls. These findings indicate that increased MMP – 1 expression in uterosacral ligaments is associated with genital prolapse. Our data are consistent with the theory that increased collagen breakdown may play an important role in the onset and development of pelvic organ prolapse POP.

MMP – 1; uterosacral ligament; genital prolapse



Author: Marko Vulić - Tomislav Strinić - Damir Buković - Snježana Tomić - Tomislav Župić - Mato Pavić - Petra Turčić - Slobodan

Source: http://hrcak.srce.hr/



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