Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico BorderReport as inadecuate


Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico Border


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Citation

Missmer, Stacey A., Lucina Suarez, Marilyn Felkner, Elaine Wang, Alfred H. Merrill, Kenneth J. Rothman, Katherine A. Hendricks. -Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas-Mexico Border- Environmental Health Perspectives 1142: 237-241. 2005

Abstract

Along the Texas-Mexico border, the prevalence of neural tube defects NTDs among Mexican-American women doubled during 1990-1991. The human outbreak began during the same crop year as epizootics attributed to exposure to fumonisin, a mycotoxin that often contaminates corn. Because Mexican Americans in Texas consume large quantities of corn, primarily in the form of tortillas, they may be exposed to high levels of fumonisins. We examined whether or not maternal exposure to fumonisins increases the risk of NTDs in offspring using a population-based case-control study. We estimated fumonisin exposure from a postpartum sphinganine:sphingosine sa:so ratio, a biomarker for fumonisin exposure measured in maternal serum, and from maternal recall of periconceptional corn tortilla intake. After adjusting for confounders, moderate 301-400 compared with low ≤100 consumption of tortillas during the first trimester was associated with increased odds ratios ORs of having an NTD-affected pregnancy OR = 2.4; 95% confidence interval, 1.1-5.3. No increased risks were observed at intakes higher than 400 tortillas OR = 0.8 for 401-800, OR = 1.0 for > 800. Based on the postpartum sa:so ratio, increasing levels of fumonisin exposure were associated with increasing ORs for NTD occurrences, except for the highest exposure category sa:so > 0.35. Our findings suggest that fumonisin exposure increases the risk of NTD, proportionate to dose, up to a threshold level, at which point fetal death may be more likely to occur. These results also call for population studies that can more directly measure individual fumonisin intakes and assess effects on the developing embryo.

SPH Epidemiology Papers -



Author: Missmer, Stacey A. - Suarez, Lucina - Felkner, Marilyn - Wang, Elaine - Merrill, Alfred H. - Rothman, Kenneth J. - Hendricks, Kat

Source: https://open.bu.edu/



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