Serum 25-Hydroxyvitamin D3 and D2 and Non-Clinical Psychotic Experiences in ChildhoodReport as inadecuate




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Objective

Non-clinical psychotic experiences are common and distressing. It has been hypothesized that early life vitamin D deficiency may be a risk factor for psychosis-related outcomes, but it is not known if circulating concentrations of 25-hydroxyvitamin D 25OHD during childhood are associated with psychosis-related outcomes or whether the two different forms of 25OHD, 25OHD3 and 25OHD2, have similar associations with psychosis-related outcomes.

Methods

We investigated the association between serum 25OHD3 and 25OHD2 concentrations and psychotic experiences in a prospective birth cohort study. Serum 25OHD3 and 25OHD2 concentrations were measured at mean age 9.8 years and psychotic experiences assessed at mean age 12.8 years by a psychologist N = 3182.

Results

Higher 25OHD3 concentrations were associated with lower risk of definite psychotic experiences adjusted odds ratio: OR 95% confidence interval: CI 0.85 0.75–0.95. Higher concentrations of 25OHD2 were associated with higher risk of suspected and definite psychotic experiences adjusted odds ratio: OR 95% confidence interval: CI 1.26 1.11, 1.43. Higher 25ODD2 concentrations were also weakly associated with definite psychotic experiences adjusted OR 95% CI 1.17 0.96, 1.43, though with wide confidence intervals including the null value.

Conclusions

Our findings of an inverse association of 25OHD3 with definite psychotic experiences is consistent with the hypothesis that vitamin D may protect against psychosis-related outcomes.



Author: Anna-Maija Tolppanen, Adrian Sayers, William D. Fraser, Glyn Lewis, Stanley Zammit, John McGrath, Debbie A. Lawlor

Source: http://plos.srce.hr/



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