Evidence of Associations between Cytokine Genes and Subjective Reports of Sleep Disturbance in Oncology Patients and Their Family CaregiversReport as inadecuate




Evidence of Associations between Cytokine Genes and Subjective Reports of Sleep Disturbance in Oncology Patients and Their Family Caregivers - Download this document for free, or read online. Document in PDF available to download.

The purposes of this study were to identify distinct latent classes of individuals based on subjective reports of sleep disturbance; to examine differences in demographic, clinical, and symptom characteristics between the latent classes; and to evaluate for variations in pro- and anti-inflammatory cytokine genes between the latent classes. Among 167 oncology outpatients with breast, prostate, lung, or brain cancer and 85 of their FCs, growth mixture modeling GMM was used to identify latent classes of individuals based on General Sleep Disturbance Scale GSDS obtained prior to, during, and for four months following completion of radiation therapy. Single nucleotide polymorphisms SNPs and haplotypes in candidate cytokine genes were interrogated for differences between the two latent classes. Multiple logistic regression was used to assess the effect of phenotypic and genotypic characteristics on GSDS group membership. Two latent classes were identified: lower sleep disturbance 88.5% and higher sleep disturbance 11.5%. Participants who were younger and had a lower Karnofsky Performance status score were more likely to be in the higher sleep disturbance class. Variation in two cytokine genes i.e., IL6, NFKB predicted latent class membership. Evidence was found for latent classes with distinct sleep disturbance trajectories. Unique genetic markers in cytokine genes may partially explain the interindividual heterogeneity characterizing these trajectories.



Author: Christine Miaskowski , Bruce A. Cooper, Anand Dhruva, Laura B. Dunn, Dale J. Langford, Janine K. Cataldo, Christina R. Baggott, J

Source: http://plos.srce.hr/



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