High-Sensitivity Cardiac Troponin-I Is Elevated in Patients with Rheumatoid Arthritis, Independent of Cardiovascular Risk Factors and InflammationReport as inadecuate




High-Sensitivity Cardiac Troponin-I Is Elevated in Patients with Rheumatoid Arthritis, Independent of Cardiovascular Risk Factors and Inflammation - Download this document for free, or read online. Document in PDF available to download.

Objectives

We examined the hypothesis that cardiac-specific troponin-I cTn-I, a biomarker of myocardial injury, is elevated in patients with rheumatoid arthritis RA.

Background

RA patients have an increased incidence of heart failure HF. Chronic myocardial injury in RA may be a mechanism for the development of HF.

Methods

We compared cTn-I concentrations measured by high-sensitivity immunoassay in 164 patients with RA and 90 controls, excluding prior or active heart failure. We examined the relationship between cTn-I concentrations and cardiovascular risk factors, inflammation, and coronary artery calcium score CACS, a measure of coronary atherosclerosis.

Results

cTn-I concentrations were 49% higher in patients with RA median 1.15 pg-mL IQR 0.73–1.92 than controls 0.77 pg-mL 0.49–1.28P<0.001. The difference remained statistically significant after adjustment for demographic characteristics P = 0.002, further adjustment for cardiovascular CV risk factors P = 0.004, inflammatory markers P = 0.008, and in a comprehensive model of CV risk factors and inflammatory markers P = 0.03. In patients with RA, cTn-I concentrations were positively correlated with age rho = 0.359, Framingham risk score FRS rho = 0.366, and systolic blood pressure rho = 0.248 all P values ≤0.001, but not with measures of inflammation or RA drug therapies. cTn-I was significantly correlated with CACS in RA in univariate analysis, but not after adjustment for age, race, sex and FRS P = 0.79. Further model adjustments for renal function and coronary artery disease confirmed the significance of the findings.

Conclusion

High-sensitivity cTn-I concentrations are elevated in patients with RA without heart failure, independent of cardiovascular risk profile and inflammatory markers. Elevated troponin concentrations in RA may indicate subclinical, indolent myocardial injury.



Author: William S. Bradham , Aihua Bian, Annette Oeser, Tebeb Gebretsadik, Ayumi Shintani, Joseph Solus, Joel Estis, Quynh Anh Lu, John T

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents