miR-26b Promotes Granulosa Cell Apoptosis by Targeting ATM during Follicular Atresia in Porcine OvaryReport as inadecuate




miR-26b Promotes Granulosa Cell Apoptosis by Targeting ATM during Follicular Atresia in Porcine Ovary - Download this document for free, or read online. Document in PDF available to download.

More than 99% of ovarian follicles undergo atresia in mammals, but the mechanism of follicular atresia remains to be elucidated. In this study, we explored microRNA miRNA regulation of follicular atresia in porcine ovary. A miRNA expression profile was constructed for healthy, early atretic, and progressively atretic follicles, and the differentially expressed miRNAs were selected and analyzed. We found that miR-26b, which was upregulated during follicular atresia, increased the number of DNA breaks and promoted granulosa cell apoptosis by targeting the ataxia telangiectasia mutated gene directly in vitro.



Author: Fei Lin, Ran Li, Zeng xiang Pan, Bo Zhou, De bing Yu, Xu guang Wang, Xue shan Ma, Jing Han, Ming Shen, Hong lin Liu

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents