Control of rodent sleeping sickness disease by surface functionalized amorphous nanosilica - Quantitative Biology > Molecular NetworksReport as inadecuate




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Abstract: Wild animals, pets, zoo animals and mammals of veterinary importance heavilysuffer from trypanosomiasis. Drugs with serious side effects are currentlymainstay of therapies used by veterinarians. Trypanosomiasis is caused byTrypanosoma sp. leading to sleeping sickness in humans. Surface modifiedhydrophobic and lipophilic amorphous nanoporous silica molecules could beeffectively used as therapeutic drug for combating trypanosomiasis. Theamorphous nanosilica was developed by top-down approach using volcanic soilderived silica Advasan; 50- 60 nm size with 3-10 nm inner pore size range anddiatomaceous earth FS; 60-80 nm size with 3-5 nm inner pore size range assource materials. According to WHO and USDA standards amorphous silica has longbeen used as feed additives for several veterinary industries and considered tobe safe for human consumption. The basic mechanism of action of thesenanosilica molecules is mediated by the physical absorption of HDL componentsin the lipophilic nanopores of nanosilica. This reduces the supply of the hostderived cholesterol, thus limiting the growth of the Trypanosoma sp. in vivo.



Author: Dipankar Seth, Mritunjay Mandal, Nitai Debnath, Ayesha Rahman, N. K. Sasmal, Sunit Mukhopadhyaya, Arunava Goswami

Source: https://arxiv.org/







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