Circadian Rhythm-Dependent Alterations of Gene Expression in Drosophila Brain Lacking Fragile X Mental Retardation ProteinReport as inadecuate




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Fragile X syndrome is caused by the loss of the FMR1 gene product, fragile X mental retardation protein FMRP. The loss of FMRP leads to altered circadian rhythm behaviors in both mouse and Drosophila; however, the molecular mechanism behind this phenomenon remains elusive. Here we performed a series of gene expression analyses, including of both mRNAs and microRNAs miRNAs, and identified a number of mRNAs and miRNAs miRNA-1 and miRNA-281 with circadian rhythm-dependent altered expression in dfmr1 mutant flies. Identification of these RNAs lays the foundation for future investigations of the molecular pathways underlying the altered circadian rhythms associated with loss of dFmr1.



Author: Shunliang Xu , Mickael Poidevin, Enji Han, Jianzhong Bi, Peng Jin

Source: http://plos.srce.hr/



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