Methadone-Mediated Autonomic Functioning of Male Patients with Heroin Dependence: The Influence of Borderline Personality PatternReport as inadecuate




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Background

We hypothesize that the population with borderline personality shows different autonomic response to methadone compared to individuals with other personalities. This study applies heart rate variability HRV measurements and the Tridimensional Personality Questionnaire TPQ to examine this hypothesis.

Methodology-Principal Findings

Forty-four male patients with heroin dependence were recruited from a methadone maintenance treatment program. Eight personality patterns were classified according to the TPQ norm used in Taiwan. The borderline pattern BP, composed of high novelty seeking, high harm avoidance and low reward dependence and the other personality patterns OP were separated into two groups. We compared the HRV profiles between the BP and OP groups. Correlation and regression analysis were performed to clarify relationship between HRV differences and the borderline index BI, a new concept defined by us, which is calculated as novelty seeking + harm avoidance – reward dependence. The HRV targets investigated included low frequency LF power, high frequency HF power, total power TP, normalized LF LF%, and LF-HF. No baseline HRV parameters showed any inter-group difference. The BP group had a significantly lower ΔHF and a higher ΔLF-HF than the OP group. The personality dimension, reward dependence, showed a negative correlation with ΔLF-HF and ΔLF%. BI was negatively correlated with ΔHF and positively correlated with ΔLF-HF and ΔLF%.

Conclusions-Significance

Borderline personality individuals show increased sympathetic activity and decreased parasympathetic activity compared to other personalities after taking methadone. The results support the hypothesis that there is an interaction between borderline personality and autonomic modulation.



Author: Wei-Lieh Huang, Yu-Hsuan Lin, Terry B. J. Kuo, Li-Ren Chang, Ying-Zai Chen, Cheryl C. H. Yang

Source: http://plos.srce.hr/



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