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The population of Argentina is the result of the intermixing between several groups, including Indigenous American, European and African populations. Despite the commonly held idea that the population of Argentina is of mostly European origin, multiple studies have shown that this process of admixture had an impact in the entire Argentine population. In the present study we characterized the distribution of Indigenous American, European and African ancestry among individuals from different regions of Argentina and evaluated the level of discrepancy between self-reported grandparental origin and genetic ancestry estimates. A set of 99 autosomal ancestry informative markers AIMs was genotyped in a sample of 441 Argentine individuals to estimate genetic ancestry. We used non-parametric tests to evaluate statistical significance. The average ancestry for the Argentine sample overall was 65% European 95%CI: 63–68%, 31% Indigenous American 28–33% and 4% African 3–4%. We observed statistically significant differences in European ancestry across Argentine regions Buenos Aires province BA 76%, 95%CI: 73–79%; Northeast NEA 54%, 95%CI: 49–58%; Northwest NWA 33%, 95%CI: 21–41%; South 54%, 95%CI: 49–59%; p<0.0001 as well as between the capital and immediate suburbs of Buenos Aires city compared to more distant suburbs 80% 95%CI: 75–86% versus 68% 95%CI: 58–77%, p = 0.01. European ancestry among individuals that declared all grandparents born in Europe was 91% 95%CI: 88–94% compared to 54% 95%CI: 51–57% among those with no European grandparents p<0.001. Our results demonstrate the range of variation in genetic ancestry among Argentine individuals from different regions in the country, highlighting the importance of taking this variation into account in genetic association and admixture mapping studies in this population.



Author: Sergio Avena, Marc Via, Elad Ziv, Eliseo J. Pérez-Stable, Christopher R. Gignoux, Cristina Dejean, Scott Huntsman, Gabriela Torr

Source: http://plos.srce.hr/



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