Parvovirus B 19 PVB19 Induced Pure Red Cell Aplasia PRCA in Immunocompromised Patient after Liver TransplantationReport as inadecuate




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Collegium antropologicum, Vol.34 No.1 March 2010. -

Presented here is a case of human parvovirus B19 PVB19 induced pure red-cell aplasia PRCA in immunocompromised patient after orthotopic liver transplantation OLT. PVB19 is a small, single-stranded DNA whose target cell is the erythroid progenitor in bone marrow. Manifestations of PVB19 infection vary with the immunologic status of the patient, ranging from asymptomatic to severe infections and PRCA. Post-transplant PRCA is induced either by immunosuppressive agents or PVB19. In the presented case, bone marrow aspiration characterized by the absence of mature erythroid precursors and detection of PVB19 DNA in blood led to treatment with high-dose intravenous human immunoglobulins IVIG and subsequent recovery of erythropoiesis. Due to insufficient antibody response in immunocompromised patients, suppression of the PVB19 infection is delayed and repetitive treatments may be administrated in attempt of reversing PRCA.

pure red-cell aplasia PRCA; parvovirus B19 PVB19; liver transplantation



Author: Anna Mrzljak - ; University of Zagreb, School of Medicine, Zagreb, Croatia Ika Kardum-Skelin - ; University of Zagreb, School of

Source: http://hrcak.srce.hr/



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