IS THERE A CORTICAL BLOOD FLOW REDISTRIBUTION PATTERN RELATED WITH PERSEVERATIVE ERROR IN SCHIZOPHRENIAReport as inadecuate




IS THERE A CORTICAL BLOOD FLOW REDISTRIBUTION PATTERN RELATED WITH PERSEVERATIVE ERROR IN SCHIZOPHRENIA - Download this document for free, or read online. Document in PDF available to download.

Psychiatria Danubina, Vol.21 No.3 June 2009. -

Background: We studied relative cortical blood flow relCBF patterns

associated to correct performance CP and perseverative error PE during Wisconsin Card Sorting Test WCST execution, in controls and patients with schizophrenia.

Subjects and methods: relCBF regional cortical blood flow rCBF - whole cortex blood flow of 10 well defined cortical regions was measured in 18 patients with schizophrenia and 13 healthy controls by a Technetium – 99 – HMPAO – SPECT, at rest and while they performed WCST.

Results: Patients made significantly more PE than controls during WCST performance. In patients, we found a significant correlation between PE and relCBF in right occipital cortex. In controls, we found a significant correlation between CP and relCBF of several cortical regions during WCST execution: left orbitofrontal cortex and left global frontal cortex positively and parietal bilateral cortex

negatively. PE was inversely correlated with relCBF in left temporal cortex.

Conclusions: Successful WCST performance is associated to a high left frontal activity in controls but not in patients. The severity of PE during WCST performance is associated to a low left frontal-temporal activity in controls and to a high right parietal-occipital activity in schizophrenia. This may represent a cortical activity redistribution pattern related to perseveration in schizophrenia.

schizophrenia; Wisconsin Card Sorting Test; SPECT; perseveration; prefrontal cortex



Author: Felipe Ortuño - ; Depart. of Psychiatry and Med. Psychology, University Clinic, University of Navarra College of Medicine, Pampl

Source: http://hrcak.srce.hr/



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