Characterization of Genome-Wide Association-Identified Variants for Atrial Fibrillation in African AmericansReport as inadecuate




Characterization of Genome-Wide Association-Identified Variants for Atrial Fibrillation in African Americans - Download this document for free, or read online. Document in PDF available to download.

Background

Despite a greater burden of risk factors, atrial fibrillation AF is less common among African Americans than European-descent populations. Genome-wide association studies GWAS for AF in European-descent populations have identified three predominant genomic regions associated with increased risk 1q21, 4q25, and 16q22. The contribution of these loci to AF risk in African American is unknown.

Methodology-Principal Findings

We studied 73 African Americans with AF from the Vanderbilt-Meharry AF registry and 71 African American controls, with no history of AF including after cardiac surgery. Tests of association were performed for 148 SNPs across the three regions associated with AF, and 22 SNPs were significantly associated with AF P<0.05. The SNPs with the strongest associations in African Americans were both different from the index SNPs identified in European-descent populations and independent from the index European-descent population SNPs r2<0.40 in HapMap CEU: 1q21 rs4845396 odds ratio OR 0.30, 95% confidence interval CI 0.13–0.67, P = 0.003, 4q25 rs4631108 OR 3.43, 95% CI 1.59–7.42, P = 0.002, and 16q22 rs16971547 OR 8.1, 95% CI 1.46–45.4, P = 0.016. Estimates of European ancestry were similar among cases 23.6% and controls 23.8%. Accordingly, the probability of having two copies of the European derived chromosomes at each region did not differ between cases and controls.

Conclusions-Significance

Variable European admixture at known AF loci does not explain decreased AF susceptibility in African Americans. These data support the role of 1q21, 4q25, and 16q22 variants in AF risk for African Americans, although the index SNPs differ from those identified in European-descent populations.



Author: Jessica T. Delaney, Janina M. Jeff, Nancy J. Brown, Mias Pretorius, Henry E. Okafor, Dawood Darbar, Dan M. Roden, Dana C. Crawfor

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents