Higher Serum Uric Acid on Admission Is Associated with Higher Short-term Mortality and Poorer Long-term Survival After Myocardial Infarction: Retrospective Prognostic StudyReport as inadecuate




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Croatian medical journal, Vol.50 No.6 December 2009. -

Aim To assess serum uric acid SUA levels determined on

admission as a potential predictor of short-term mortality

and long-term survival in acute myocardial infarction AMI

patients.

Method Data for this retrospective prognostic study were

drawn from the patient database of the Varaždin County

General Hospital in Varaždin, Croatia. We included consecutive

patients with verified AMI admitted within 48 hours

since the symptom onset during the period between 1

January 1996 and 31 December 2001. Long-term survival-

mortality data were collected through direct contacts

with patients and search of the community death registries.

Relative risks RR and hazard ratios HR by 10 μmol-

L increase in SUA were determined using modified Poisson

regression with robust error variance and proportional

hazard regression, respectively.

Results A total of 621 patients age 27-90 years, 64.7% men,

77.5% AMI with ST elevation, SUA 63-993 μmol-L were included.

Higher SUA on admission was independently associated

with higher in-hospital mortality RR, 1.016; 95%

confidence interval CI, 1.001-1.031, P = 0.043 and higher

thirty-day mortality RR, 1.016; 95% CI, 1.003-1.029,

P = 0.018. Considered covariates were demographics, preindex

event cardiovascular morbidity and treatment, onadmission

serum creatinine, total cholesterol and triglycerides,

AMI characteristics, and peak creatine phosphokinase.

Higher SUA on admission was also independently associated

with poorer long-term survival ie, higher all-cause mortality

HR, 1.105; 95% CI, 1.020-1.195, P = 0.010. Considered

covariates were demographics, laboratory variables on admission,

AMI characteristics, peak creatine phosphokinase,

acute complications, and treatment at discharge.

Conclusion Higher serum uric acid determined on admission

is associated with higher in-hospital mortality and thirty-

day mortality and poorer long-term survival after AMI.

serum uric acid; acute myocardial infarction; mortality; all-cause mortality



Author: Siniša Car - ; Department of Internal Medicine, Varaždin County General Hospital, Varaždin, Croatia Vladimir Trkulja - ; Depar

Source: http://hrcak.srce.hr/



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