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Abstract: 3- untranslated regions 3- UTRs contain binding sites for many regulatoryelements, and in particular for microRNAs miRNAs. The importance ofmiRNA-mediated post-transcriptional regulation has become increasingly clear inthe last few years.We propose two complementary approaches to the statistical analysis ofoligonucleotide frequencies in mammalian 3- UTRs aimed at the identification ofcandidate binding sites for regulatory elements. The first method is based onthe identification of sets of genes characterized by evolutionarily conservedoverrepresentation of an oligonucleotide. The second method is based on theidentification of oligonucleotides showing statistically significant strandasymmetry in their distribution in 3- UTRs.Both methods are able to identify many previously known binding sites locatedin 3-UTRs, and in particular seed regions of known miRNAs. Many new candidatesare proposed for experimental verification.



Author: Davide Cora, Ferdinando Di Cunto, Michele Caselle, Paolo Provero

Source: https://arxiv.org/







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