Use of Liquid-Based Cytology LBC and Cell Blocks from Cell Remnants for Cytologic, Immunohistochemical, and Immunocytochemical Diagnosis of MalignancyReport as inadecuate




Use of Liquid-Based Cytology LBC and Cell Blocks from Cell Remnants for Cytologic, Immunohistochemical, and Immunocytochemical Diagnosis of Malignancy - Download this document for free, or read online. Document in PDF available to download.

Great advances in screening have lowered the death rate from cervical cancer in the advanced countries. The major advances in cervical cancer screening include the Papanicolaou Pap test and liquid-based cytology LBC. In this study, we aimed to use cell remnants from LBC specimens from uterine cervix and endometrium, aspirates from breast and thyroid tumors, and liquid samples ascites, pleural effusion, and urine. Cell blocks made from cell remnants of LBC specimens were immunohistochemically or immunocytochemically stained for several biomarkers including certain tumor markers such together with hematoxylin and eosin staining for accurate diagnosis of malignancies in different samples. The findings from the cell blocks stained with these biomarkers combined with those from Pap stain led to easily diagnosis of the presence or absence of malignancies. Our findings suggest the utility of LBC and cell blocks from cell remnants in cytologic diagnosis in certain specimens.

KEYWORDS

LBC; Cell Remnants; Cell Block; Immunohistohemistry; Immunocytochemistry; Biomarkers; Cancer; Accurate Diagnosis

Cite this paper

H. Sakamoto, M. Takenaka, K. Ushimaru and T. Tanaka -Use of Liquid-Based Cytology LBC and Cell Blocks from Cell Remnants for Cytologic, Immunohistochemical, and Immunocytochemical Diagnosis of Malignancy,- Open Journal of Pathology, Vol. 2 No. 3, 2012, pp. 58-65. doi: 10.4236-ojpathology.2012.23012.





Author: Hirofumi Sakamoto, Makiyo Takenaka, Kazuki Ushimaru, Takuji Tanaka

Source: http://www.scirp.org/



DOWNLOAD PDF




Related documents