A Retrospective Analysis of the Haemodynamic and Metabolic Effects of Fluid Resuscitation in Vietnamese Adults with Severe Falciparum MalariaReport as inadecuate




A Retrospective Analysis of the Haemodynamic and Metabolic Effects of Fluid Resuscitation in Vietnamese Adults with Severe Falciparum Malaria - Download this document for free, or read online. Document in PDF available to download.

Background

Optimising the fluid resuscitation of patients with severe malaria is a simple and potentially cost-effective intervention. Current WHO guidelines recommend central venous pressure CVP guided, crystalloid based, resuscitation in adults.

Methods

Prospectively collected haemodynamic data from intervention trials in Vietnamese adults with severe malaria were analysed retrospectively to assess the responses to fluid resuscitation.

Results

43 patients were studied of whom 24 received a fluid load. The fluid load resulted in an increase in cardiac index mean increase: 0.75 L-min-m2 95% Confidence interval CI: 0.41 to 1.1, but no significant change in acid-base status post resuscitation mean increase base deficit 0.6 mmol-L 95% CI: −0.1 to 1.3. The CVP and PAoP pulmonary artery occlusion pressure were highly inter-correlated rs = 0.7, p<0.0001, but neither were correlated with acid-base status arterial pH, serum bicarbonate, base deficit or respiratory status PaO2-FiO2 ratio. There was no correlation between the oxygen delivery DO2 and base deficit at the 63 time-points where they were assessed simultaneously rs = −0.09, p = 0.46.

Conclusions

In adults with severe falciparum malaria there was no observed improvement in patient outcomes or acid-base status with fluid loading. Neither CVP nor PAoP correlated with markers of end-organ perfusion or respiratory status, suggesting these measures are poor predictors of their fluid resuscitation needs.



Author: Nguyen Hoan Phu , Josh Hanson , Delia Bethell, Nguyen Thi Hoang Mai, Tran Thi Hong Chau, Ly Van Chuong, Pham Phu Loc, Dinh Xuan S

Source: http://plos.srce.hr/



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