A Genetic Polymorphism rs17251221 in the Calcium-Sensing Receptor Gene CASR Is Associated with Stone Multiplicity in Calcium NephrolithiasisReport as inadecuate




A Genetic Polymorphism rs17251221 in the Calcium-Sensing Receptor Gene CASR Is Associated with Stone Multiplicity in Calcium Nephrolithiasis - Download this document for free, or read online. Document in PDF available to download.

Calcium nephrolithiasis is one of the most common causes of renal stones. While the prevalence of this disease has increased steadily over the last 3 decades, its pathogenesis is still unclear. Previous studies have indicated that a genetic polymorphism rs17251221 in the calcium-sensing receptor gene CASR is associated with the total serum calcium levels. In this study, we collected DNA samples from 480 Taiwanese subjects 189 calcium nephrolithiasis patients and 291 controls for genotyping the CASR gene. Our results indicated no significant association between the CASR polymorphism rs17251221 and the susceptibility of calcium nephrolithiasis. However, we found a significant association between rs17251221 and stone multiplicity. The risk of stone multiplicity was higher in patients with the GG+GA genotype than in those with the AA genotype chi-square test:P = 0.008;odds ratio  =  4.79;95% confidence interval, 1.44–15.92;Yates- correction for chi-square test:P = 0.013. In conclusion, our results provide evidence supporting the genetic effects of CASR on the pathogenesis of calcium nephrolithiasis.



Author: Yii-Her Chou, Peng Yeong Woon, Wei-Chiao Chen, Yu-Wen Hsu, Jer-Ming Chang, Daw-Yang Hwang, Yi-Ching Chiu, Ho-Chang Kuo, Wei-Pin C

Source: http://plos.srce.hr/



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