The Mechanisms of UV Radiation in the Development of Malignant MelanomaReport as inadecuate

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Collegium antropologicum, Vol.31 - Supplement 1 No.1 January 2007. -

The sunlight was one of the first agents recognized to be carcinogenic for humans. There is convincing evidence from

epidemiologic studies that exposure to solar radiation is the major cause of cutaneous melanoma in light-pigmented populations

and plays a role in the increasing incidence of this malignancy. The molecular mechanisms by which UV radiation

exerts its varied effects are not completely understood, however, it is considered that UVA and UVB are equally critical

players in melanoma formation. Whereas UVA can indirectly damage DNA through the formation of reactive oxygen

radicals, UVB can directly damage DNA causing the apoptosis of keratinocytes by forming the sunburn cells. Besides action

through mutations in critical regulatory genes, UV radiation may promote cancer through indirect mechanisms,

e.g. immunosuppression and dysregulation of growth factors. The carcinogenic process probably involves multiple sequential

steps, some, but not all of which involve alterations in DNA structure.

melanoma; UV radiation; photoimmunology; oncogene

Author: Mirna Šitum - Marija Buljan - Suzana Ožanić Bulić - Dubravka Šimić -



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