The Interleukin-1 Receptor Antagonist Gene and the Inhibitor of Kappa B-Like Protein Gene Polymorphisms Are Not Associated with Myocardial Infarction in Slovene Population with Type 2 DiabetesReport as inadecuate




The Interleukin-1 Receptor Antagonist Gene and the Inhibitor of Kappa B-Like Protein Gene Polymorphisms Are Not Associated with Myocardial Infarction in Slovene Population with Type 2 Diabetes - Download this document for free, or read online. Document in PDF available to download.

Collegium antropologicum, Vol.31 No.2 April 2007. -

In this study we investigated the association of the interleukin-1 receptor antagonist gene variable number tandem repeat

IL1RN VNTR polymorphism and of the inhibitor of kappa B-like protein IKBL gene polymorphism with myocardial

infarction MI in a group of patients with type 2 diabetes. The IL1RN VNTR and the IKBL+738T>C gene polymorphisms

were tested in 374 Caucasians: 151 cases with MI and 223 subjects with no history of coronary artery disease.

The IL1RN VNTR polymorphism was not a risk factor for MI in Caucasians with type 2 diabetes genotype 22 vs. the

rest: odds ratio OR 1.6; 95% confidence interval CI = 0.8–3.5; p=0.2. We also failed to demonstrate that IKBL+

738T>C gene polymorphism was associated with MI in patients with type 2 diabetes OR =0.9; 95% CI = 0.3–2.6;

p=0.9. We provide evidence that the IL1RN VNTR and the IKBL+738T>C gene polymorphisms are not risk factors for

MI in Caucasians with type 2 diabetes.

interleukin-1 receptor antagonist polymorphism; inhibitor of kappa B-like protein gene polymorphism; myocardial infarction; type 2 diabetes



Author: Stojan Kariž - Aleksandra Milutinović - Dejan Bregar - Ibrahim Terzić - Rifet Terzić - Luca Lovrečić - Magdalena Herova - H

Source: http://hrcak.srce.hr/



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