Operant Sensation Seeking Requires Metabotropic Glutamate Receptor 5 mGluR5Report as inadecuate




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Pharmacological and genetic studies have suggested that the metabotropic glutamate receptor 5 mGluR5 is critically involved in mediating the reinforcing effects of drugs of abuse, but not food. The purpose of this study was to use mGluR5 knockout KO, heterozygous Het, and wildtype WT mice to determine if mGluR5 modulates operant sensation seeking OSS, an operant task that uses varied sensory stimuli as a reinforcer. We found that mGluR5 KO mice had significantly reduced OSS responding relative to WT mice, while Het mice displayed a paradoxical increase in OSS responding. Neither KO nor Het mice exhibited altered operant responding for food as a reinforcer. Further, we assessed mGluR5 KO, Het and WT mice across a battery of cocaine locomotor, place preference and anxiety related tests. Although KO mice showed expected differences in some locomotor and anxiety measures, Het mice either exhibited no phenotype or an intermediate one. In total, these data demonstrate a key role for mGluR5 in OSS, indicating an important role for this receptor in reinforcement-based behavior.



Author: Christopher M. Olsen , Daniel S. Childs, Gregg D. Stanwood, Danny G. Winder

Source: http://plos.srce.hr/



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