Prognostic Impact of Lymphocytes in Soft Tissue SarcomasReport as inadecuate




Prognostic Impact of Lymphocytes in Soft Tissue Sarcomas - Download this document for free, or read online. Document in PDF available to download.

Purpose

The purpose of this study was to clarify the prognostic significance of lymphocyte infiltration in soft tissue sarcomas STS. Prognostic markers in potentially curable STS should guide therapy after surgical resection. The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting roles during cancer development.

Experimental Design

Tissue microarrays from 249 patients with STS were constructed from duplicate cores of viable and representative neoplastic tumor areas. Immunohistochemistry was used to evaluate the CD3+, CD4+, CD8+, CD20+ and CD45+ lymphocytes in tumors.

Results

In univariate analyses, increased numbers of CD4+ P = 0.008 and CD20+ P = 0.006 lymphocytes in tumor correlated significantly with an improved disease-specific survival DSS in patients with wide resection margins n = 108. In patients with non-wide resection margins n = 141 increased numbers of CD3+ P = 0.028 lymphocytes in tumor correlated significantly with shorter DSS. In multivariate analyses, a high number of CD20+ lymphocytes HR = 5.5, CI 95%  = 1.6–18.6, P = 0.006 in the tumor was an independent positive prognostic factor for DSS in patients with wide resections margins.

Conclusions

High density of CD20+ lymphocytes in STS with wide resection margins is an independent positive prognostic indicator for these patients. Further research is needed to define if CD20+ cells can modify tumors in a way that reduces disease progression and metastatic potential.



Author: Sveinung W. Sorbye , Thomas Kilvaer, Andrej Valkov, Tom Donnem, Eivind Smeland, Khalid Al-Shibli, Roy M. Bremnes, Lill-Tove Busun

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents