Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in a Patient with Amyotrophic Lateral Sclerosis and Frontotemporal DementiaReport as inadecuate




Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in a Patient with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia - Download this document for free, or read online. Document in PDF available to download.

Collegium antropologicum, Vol.32 - Supplement 1 No.1 May 2008. -

Magnetic resonance imaging MRI and magnetic resonance spectroscopy MRS have been investigated in a single

neurodegenerative disease manifesting as either amyotrophic lateral sclerosis ALS or frontotemporal dementia FTD

alone, but have not been examined in combined disorders such as ALS with FTD ALS-FTD. To our knowledge, this

study is the first attempt to demonstrate relationship between MRI abnormalities and MR spectroscopic metabolite changes

of the motor cortex, frontal white matter and corticospinal tract in a patient with the diagnosis of ALS with probable

upper motor neuron signs ALS-PUMNS and FTD. Patient presented underwent MRI of the brain and MRS. The ratio

of N-acetylaspartate NAA to creatine Cr, choline to Cr, myo-inositol mI to Cr and glutamate-glutamine Glx to Cr

were derived from peak area measurement. Spectra from the right motor cortex, frontal white matter and corticospinal

tract were obtained. MR images were evaluated for sulcus centralis enlargement, corticospinal tract hyperintensity and

frontal lobes atrophy. Spectra showed reduced NAA-Cr and Glx-Cr ratio, yet the ratio of Cho-Cr exhibited significant elevation.

MR images revealed sulcus centralis enlargement, high signal intensity of corticospinal tract and atrophy of both

frontal lobes. Proton spectroscopic metabolic changes in a current patient fully correlate with previously reported MRS

metabolic changes in ALS alone. Surprisingly, normal mI glial marker values have been found in almost all measured

voxels of interest except in the frontal white matter. These findings differ from the previous findings in ALS or FTD

alone. In conclusion, these findings support the concept that ALS, FTD and ALS-FTD may represent different manifestations

of a single pathological continuum.

magnetic resonance imaging; magnetic resonance spectroscopy; amyotrophic lateral sclerosis; frontotemporal dementia



Author: Helena Šarac - Marija Žagar - Davorka Vranješ - Neven Henigsberg - Ervina Bilić - Goran Pavliša -

Source: http://hrcak.srce.hr/



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