Magnetic Resonance Spectroscopy and Measurement of Tau Epitopes of Autopsy Proven Sporadic Creutzfeldt-Jakob Disease in a Patient with Non-Specific Initial EEG, MRI and Negative 14-3-3 ImmunoblotReport as inadecuate




Magnetic Resonance Spectroscopy and Measurement of Tau Epitopes of Autopsy Proven Sporadic Creutzfeldt-Jakob Disease in a Patient with Non-Specific Initial EEG, MRI and Negative 14-3-3 Immunoblot - Download this document for free, or read online. Document in PDF available to download.

Collegium antropologicum, Vol.32 - Supplement 1 No.1 May 2008. -

Limited potential of electroencephalogram EEG, magnetic resonance images MRI and cerebrospinal fluid CSF

test for 14-3-3 protein in the clinical diagnosis of sporadic Creutzfeldt-Jakob disease sCJD resulted in developments in

diagnostic premortem tehniques. Recent studies provided evidence that magnetic resonance spectroscopy MRS and

measurement of total- tau T-tau and phospho-tau P-tau may be useful to identify patients with CJD. We combined detected

metabolic changes in the brain by MRS and measured T-tau and tau-pT181 by ELISA, and tau-pT231 by Westernblot

in a patient with autopsy proven sCJD. Our results show that in contrast to negative CSF 14-3-3 protein, nonspecific

EEG and MRI, MRS revealed metabolic alterations in regions of the brain that has appeared normal on MRI,

and tau tests has shown measurable levels of phosphorylated and non-phosphorylated isoforms in CSF. We conclude that

rapidly progressive dementia with negative 14-3-3 test and non-specific initial EEG and MRI must still be considered in

the differential diagnosis of the sCJD. Combination of serial functional MRI along with MRS study and measurement of

tau ratio could improve the early diagnosis of sCJD. The current case is the first attempt to study results of the use of

MRS and tau tests in a case of sCJD with diagnostic dilemma.

sporadic Creutzfeldt-Jakob disease; magnetic resonance spectroscopy; tau-protein test



Author: Helena Šarac - Sanja Hajnšek - Silvio Bašić - Neven Henigsberg - Marko Radoš - Goran Šimić -

Source: http://hrcak.srce.hr/



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