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Gynaecologia et perinatologia : journal for gynaecology, perinatology, reproductive medicine and ultrasonic diagnostics, Vol.15 No.4 December 2006. -

Blighted ovum is a form of miscarriage, involving the absence or disappearance of an embryo very early in pregnancy. Due to contemporary lack of understanding of the nature of blighted ovum, our objective was to demonstrate the glycosylation patterns of placental proteins in this failure of pregnancy. Six placentas were taken from women with blighted ovum and twentyone placentas were provided from healthy women undergoing elective termination of normal pregnancies. Olygosaccharide branches were detected by Western-blot method using lectins: SNA and PHA-E, after preliminary separation of proteins by discontinuous SDS-PAG electrophoresis. Much stronger expression of GP74 has been identified in blighted ovum at the beginning of the eleventh week of gestation with PHA-E, than in normal placenta. The same result was obtained for GP25 being stronger in blighted ovum at the end of eleventh week with SNA. It is possible to conclude that the differences in glycoprotein changes beetwen the blighted ovum and the normal placenta, can only be found at the quantitative level, but not at the qualitative level.

glycoproteins; lectins; blighted ovum



Author: Alan Šerman - ; Department of Gynaecology and Obstetrics, General Hospital »Sveti Duh«, Zagreb, Croatia Ljiljana Šerman - ; F

Source: http://hrcak.srce.hr/



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