Visualization of Coronary Wall Atherosclerosis in Asymptomatic Subjects and Patients with Coronary Artery Disease Using Magnetic Resonance ImagingReport as inadecuate




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Background

Magnetic resonance imaging MRI is sensitive to early atherosclerotic changes such as positive remodeling in patients with coronary artery disease CAD. We assessed prevalence, quality, and extent of coronary atherosclerosis in a group of healthy subjects compared to patients with confirmed CAD.

Methodology

Twenty-two patients with confirmed CAD 15M, 7F, mean age 60.4±10.4 years and 26 healthy subjects without history of CAD 11M, 15F, mean age 56.1±4.4 years underwent MRI of the right coronary artery RCA and vessel wall MR-CVW on a clinical 1.5T MR-scanner. Wall thickness measurements of both groups were compared.

Principal Findings

Stenoses of the RCA both < and ≥50% on CAG were present in all patients. In 21-22 patients, stenoses detected at MRI corresponded to stenoses detected with conventional angiography. In 19-26 asymptomatic subjects, there was visible luminal narrowing in the MR luminography images. Fourteen of these subjects demonstrated corresponding increase in vessel wall thickness. In 4-26 asymptomatic subjects, vessel wall thickening without luminal narrowing was present. Maximum and mean wall thicknesses in patients were significantly higher 2.16 vs 1.92 mm, and 1.38 vs 1.22 mm, both p<0.05.

Conclusions

In this cohort of middle-aged individuals, both patients with stable angina and angiographically proven coronary artery disease, as well as age-matched asymptomatic subjects. exhibited coronary vessel wall thickening detectable with MR coronary vessel wall imaging. Maximum and mean wall thicknesses were significantly higher in patients. The vast majority of asymptomatic subjects had either positive remodeling without luminal narrowing, or non-significant stenosis.

Trial registration

ClinicalTrials.gov NCT00456950



Author: Suzanne C. Gerretsen, M. Eline Kooi, Alfons G. Kessels, Simon Schalla, Marcus Katoh, Rob J. van der Geest, Warren J. Manning, Joh

Source: http://plos.srce.hr/



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