Changes in the Viral Distribution Pattern after the Appearance of the Novel Influenza A H1N1 pH1N1 Virus in Influenza-Like Illness Patients in PeruReport as inadecuate




Changes in the Viral Distribution Pattern after the Appearance of the Novel Influenza A H1N1 pH1N1 Virus in Influenza-Like Illness Patients in Peru - Download this document for free, or read online. Document in PDF available to download.

Background

We describe the temporal variation in viral agents detected in influenza like illness ILI patients before and after the appearance of the ongoing pandemic influenza A H1N1 pH1N1 in Peru between 4-January and 13-July 2009.

Methods

At the health centers, one oropharyngeal swab was obtained for viral isolation. From epidemiological week EW 1 to 18, at the US Naval Medical Research Center Detachment NMRCD in Lima, the specimens were inoculated into four cell lines for virus isolation. In addition, from EW 19 to 28, the specimens were also analyzed by real time-polymerase-chain-reaction rRT-PCR.

Results

We enrolled 2,872 patients: 1,422 cases before the appearance of the pH1N1 virus, and 1,450 during the pandemic. Non-pH1N1 influenza A virus was the predominant viral strain circulating in Peru through EW 18, representing 57.8% of the confirmed cases; however, this predominance shifted to pH1N1 51.5% from EW 19–28. During this study period, most of pH1N1 cases were diagnosed in the capital city Lima followed by other cities including Cusco and Trujillo. In contrast, novel influenza cases were essentially absent in the tropical rain forest jungle cities during our study period. The city of Iquitos Jungle had the highest number of influenza B cases and only one pH1N1 case.

Conclusions

The viral distribution in Peru changed upon the introduction of the pH1N1 virus compared to previous months. Although influenza A viruses continue to be the predominant viral pathogen, the pH1N1 virus predominated over the other influenza A viruses.



Author: Victor Alberto Laguna-Torres , Jorge Gómez, Patricia V. Aguilar, Julia S. Ampuero, Cesar Munayco, Víctor Ocaña, Juan Pérez, M

Source: http://plos.srce.hr/



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