Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in RatsReport as inadecuate




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In this study, we investigated whether increases in hippocampal blood flow HBF by tooth pulp stimulation TPS are mediated via the activation of cyclooxygenase-2 COX-2. We measured mean arterial blood pressure MABP and HBF in urethane-anesthetized rats using laser Doppler flowmetry and examined the effects of etodolac, a specific COX-2 inhibitor, on TPS-induced MABP and HBF responses. The MABP response was not attenuated by the intraperitoneal i.p. administration of etodolac 10 mg-kg; however, the HBF response was significantly attenuated by etodolac administration. These results suggest that COX-2 may be involved in the mechanisms regulating TPS-induced HBF responses.

KEYWORDS

Cyclooxygenase-2 COX-2, Etodolac, Fear Memory, Hippocampal Blood Flow, Mean Arterial Blood Pressure, Tooth Pulp Stimulation

Cite this paper

M. Hasegawa, J. Hada, T. Abe, N. Ohtsu, K. Honda and M. Urade -Etodolac Attenuates Hippocampal Blood Flow Responses Induced by Tooth Pulp Stimulation in Rats,- Neuroscience and Medicine, Vol. 2 No. 3, 2011, pp. 295-298. doi: 10.4236-nm.2011.23038.





Author: Makoto Hasegawa, Junichi Hada, Tetsuya Abe, Nao Ohtsu, Kousuke Honda, Masahiro Urade

Source: http://www.scirp.org/



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