Mal-SRF Is Dispensable for Cell Proliferation in DrosophilaReport as inadecuate




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The Mal-SRF transcription factor is regulated by the level of G-actin in cells and has important roles in cell migration and other actin-dependent processes in Drosophila. A recent report suggests that Mal-SRF and an upstream regulator, Pico, are required for cell proliferation and tissue growth in Drosophila. I find otherwise. Mutation of Mal or SRF does not affect cell proliferation in the fly wing. Furthermore, I cannot reproduce the reported effects of Pico RNAi or Pico overexpression on body size. Nevertheless, I can confirm that overexpression of Pico or Mal causes tissue overgrowth specifically in the fly wing - where SRF is most highly expressed. My results indicate that Mal-SRF can promote tissue growth when abnormally active, but is not normally required for tissue growth during development.



Author: Barry J. Thompson

Source: http://plos.srce.hr/



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