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In vitro studies suggest Amyloid Precursor Protein Gene APP is involved in interaction with the extracellular matrix, neurite growth, adhesion, development, synaptic function, platelet function, and interaction with GTP binding proteins. In vivo experiments show a role in embryonic development, response to cerebral excitotoxicity and gliosis, response to brain injury including ischaemia, hypothalamic function, locomotor function, learning and memory. In vitro observations indicate Aβ has a role in amyloid formation, excitotoxic neuronal injury, tachykinin interaction, endothelial vasoconstrictor response, calcium and oxidative stress, free radical interaction, cell membrane fluidity, apoptosis, astrocyte stimulation, and microglial interaction. Other studies suggest important roles for Aβ oligomers in synaptic function and as an antimicrobial peptide. In vivo investigations show involvement in memory function, the blood brain barrier, and tachykinin response to cerebral injury.

KEYWORDS

Amyloid Precursor Protein Gene

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P. Panegyres and E. Atkins -The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: II Experimental Evidence and Clinical Studies,- Neuroscience and Medicine, Vol. 2 No. 3, 2011, pp. 239-267. doi: 10.4236-nm.2011.23033.





Author: Peter K. Panegyres, Emily R. Atkins

Source: http://www.scirp.org/



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