Immune Augmentation of Injectable PLGA – Dextran PLDEX a Double Polymeric Microspheres as an Adjuvant for Hepatitis B VaccineReport as inadecuate




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A new method has been developed to prepare microspheres by blending PLGA and dextran polymers PLDEX using solvent evaporation technique. Recombinant hepatitis B vaccine HBsAg was incorporated in to the double polymeric system. The objective of this study was to investigate the feasibility of PLDEX polymeric microspheres as an adjuvant for hepatitis B vaccine HBsAg. The present study demonstrates the immunogenicity profile of HBsAg encapsulated in PLDEX and compared their efficacy with alum adsorbed HBsAg. The single intramuscular injection of HBsAg loaded PLDEX microspheres in Wistar rats resulted satisfactory antibody titers. Based on in vivo findings PLDEX microspheres were able induce satisfactory immune response.

KEYWORDS

HBsAg; PLGA – Dextran Microspheres; Vaccine Delivery; Immunogenicity

Cite this paper

S. Moni, S. Natarajapillai and M. Safhi -Immune Augmentation of Injectable PLGA – Dextran PLDEX a Double Polymeric Microspheres as an Adjuvant for Hepatitis B Vaccine,- World Journal of Vaccines, Vol. 1 No. 3, 2011, pp. 104-108. doi: 10.4236-wjv.2011.13011.





Author: Sivakumar Sivagurunathan Moni, Sukumaran Natarajapillai, Mohammed M. Safhi

Source: http://www.scirp.org/



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